01493nas a2200241   4500000000100000008004100001653002200042653002400064653001500088653002300103653001100126653001800137653001900155100001500174700001400189700001300203245007800216856007900294300001000373490000600383520084800389022001401237       2014                            d10aTrypanosoma cruzi10aTopography, Medical10aRecurrence10aNeglected Diseases10aHumans10aGlobal health10aChagas disease1 aAndrade DV1 aGollob KJ1 aDutra WO00aAcute chagas disease: new global challenges for an old neglected disease.  uhttp://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003010   ae30100 v83 a<p>Editor's Abstract:</p>

<p>Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although over 100 years have passed since the discovery of Chagas disease, it still presents an increasing problem for global public health. A plethora of information concerning the chronic phase of human Chagas disease, particularly the severe cardiac form, is available in the literature. However, information concerning events during the acute phase of the disease is scarce.</p>

<p>In this review, we will discuss (1) the current status of acute Chagas disease cases globally, (2) the immunological findings related to the acute phase and their possible influence in disease outcome, and (3) reactivation of Chagas disease in immunocompromised individuals, a key point for transplantation and HIV infection management.</p>
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