Helminths are parasitic worms that coevolve with their host, usually resulting in long-term persistence through modulating host immunity. The multifarious mechanisms altering the immune system induced by helminths have significant implications on the control of coinfecting pathogens such as viruses. Here, we explore the recent literature to highlight the main immune alterations and mechanisms that affect the control of viral coinfection. Insights from these mechanisms are valuable in the understanding of clinical observations in helminth-prevalent areas and in the design of new therapeutic and vaccination strategies to control viral diseases.
BT - Trends in Parasitology DO - 10.1016/j.pt.2023.02.007 IS - 5 LA - Eng N2 -Helminths are parasitic worms that coevolve with their host, usually resulting in long-term persistence through modulating host immunity. The multifarious mechanisms altering the immune system induced by helminths have significant implications on the control of coinfecting pathogens such as viruses. Here, we explore the recent literature to highlight the main immune alterations and mechanisms that affect the control of viral coinfection. Insights from these mechanisms are valuable in the understanding of clinical observations in helminth-prevalent areas and in the design of new therapeutic and vaccination strategies to control viral diseases.
PB - Elsevier BV PY - 2023 SP - 358 EP - 372 T2 - Trends in Parasitology TI - Parasitic worms affect virus coinfection: a mechanistic overview UR - https://www.cell.com/action/showPdf?pii=S1471-4922%2823%2900040-5 VL - 39 SN - 1471-4922 ER -