TY - JOUR
KW - General Biochemistry, Genetics and Molecular Biology
KW - General Agricultural and Biological Sciences
KW - General Medicine
AU - Mersha TT
AU - Mekonnen Wolde B
AU - Shumuye NA
AU - Hailu AB
AU - Mohammed AH
AU - Redda YT
AU - Abera BH
AU - Menghistu HT
AU - Simuunza MC
AB - <jats:p>Neglected tropical zoonotic diseases (NTZDs) continue to have a major effect on the health of humans and animals. In this study, a one health approach was used to prioritize and rank neglected tropical zoonotic diseases at the regional and zonal levels in Tigray National Regional State, Ethiopia. For prioritization of NTZDs a cross-sectional study through a structured questionnaire was administered to 313 health experts from human and animal health sectors. In addition, focus group discussions (FGD) were held with purposively selected key informants. Descriptive, and Multivariable analysis was applied to report the results and a ranked list of diseases was developed at the zonal and regional level. In the region, 8 of the 12 World Health Organization listed NTZDs were considered major diseases including anthrax, brucellosis, bovine tuberculosis, taeniasis, leishmaniasis, rabies, schistosomiasis, and soil-transmitted helminths. Considering the zoonotic and socioeconomic importance of the diseases at the regional level, rabies ranked 1<jats:sup>st</jats:sup>whereas anthrax, bovine tuberculosis, leishmaniasis, and brucellosis were ranked from 2<jats:sup>nd</jats:sup> to 5<jats:sup>th</jats:sup>, respectively. The FGD result also supported the prioritization result. The Multivariable analysis showed a statistically significant difference in the zonal distribution of anthrax (р = 0.009, OR = 1.16), taeniasis (p&lt;0.001, OR = 0.82), leishmaniasis (p&lt;0.001, OR = 1.91), rabies (p = 0.020, OR = 0.79) and soil-transmitted helminths (p = 0.007, OR = 0.87) but not for brucellosis (p = 0.585), bovine tuberculosis (p = 0.505), and schistosomiasis (p = 0.421). Anthrax (p&lt;0.001, OR = 26.68), brucellosis (p&lt;0.001, OR = 13.18), and taeniasis (p&lt;0.001, OR = 6.17) were considered as the major zoonotic diseases by veterinary practitioners than human health practitioners whereas, leishmaniasis was recognized as a major health challenge by human health professionals. Understanding the priority diseases in the region is supportive for informed decision-making and prioritizes the limited resources to use. Furthermore, strengthening the collaboration between human and animal health professions is important to control the diseases.</jats:p>
BT - PLOS ONE
DO - 10.1371/journal.pone.0254071
IS - 7
LA - eng
N2 - <jats:p>Neglected tropical zoonotic diseases (NTZDs) continue to have a major effect on the health of humans and animals. In this study, a one health approach was used to prioritize and rank neglected tropical zoonotic diseases at the regional and zonal levels in Tigray National Regional State, Ethiopia. For prioritization of NTZDs a cross-sectional study through a structured questionnaire was administered to 313 health experts from human and animal health sectors. In addition, focus group discussions (FGD) were held with purposively selected key informants. Descriptive, and Multivariable analysis was applied to report the results and a ranked list of diseases was developed at the zonal and regional level. In the region, 8 of the 12 World Health Organization listed NTZDs were considered major diseases including anthrax, brucellosis, bovine tuberculosis, taeniasis, leishmaniasis, rabies, schistosomiasis, and soil-transmitted helminths. Considering the zoonotic and socioeconomic importance of the diseases at the regional level, rabies ranked 1<jats:sup>st</jats:sup>whereas anthrax, bovine tuberculosis, leishmaniasis, and brucellosis were ranked from 2<jats:sup>nd</jats:sup> to 5<jats:sup>th</jats:sup>, respectively. The FGD result also supported the prioritization result. The Multivariable analysis showed a statistically significant difference in the zonal distribution of anthrax (р = 0.009, OR = 1.16), taeniasis (p&lt;0.001, OR = 0.82), leishmaniasis (p&lt;0.001, OR = 1.91), rabies (p = 0.020, OR = 0.79) and soil-transmitted helminths (p = 0.007, OR = 0.87) but not for brucellosis (p = 0.585), bovine tuberculosis (p = 0.505), and schistosomiasis (p = 0.421). Anthrax (p&lt;0.001, OR = 26.68), brucellosis (p&lt;0.001, OR = 13.18), and taeniasis (p&lt;0.001, OR = 6.17) were considered as the major zoonotic diseases by veterinary practitioners than human health practitioners whereas, leishmaniasis was recognized as a major health challenge by human health professionals. Understanding the priority diseases in the region is supportive for informed decision-making and prioritizes the limited resources to use. Furthermore, strengthening the collaboration between human and animal health professions is important to control the diseases.</jats:p>
PB - Public Library of Science (PLoS)
PY - 2021
EP - e0254071
T2 - PLOS ONE
TI - Prioritization of neglected tropical zoonotic diseases: A one health perspective from Tigray region, Northern Ethiopia
UR - https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0254071&type=printable
VL - 16
SN - 1932-6203
ER -