TY - JOUR
KW - Trachoma
KW - Tetracycline
KW - Single-Blind Method
KW - Secondary Prevention
KW - Randomized Controlled Trials as Topic
KW - Ophthalmologic Surgical Procedures
KW - Humans
KW - Hair Diseases
KW - Eyelid Diseases
KW - Eyelashes
KW - Ethiopia
KW - Combined Modality Therapy
KW - Chlamydia trachomatis
KW - Azithromycin
KW - Anti-Bacterial Agents
KW - Adult
KW - Adolescent
AU - West E
AU - Alemayehu W
AU - Munoz B
AU - Melese M
AU - Imeru A
AU - West S
AB - <p>Trachoma is the leading infectious cause of blindness worldwide. Surgery is available to correct trichiasis, which results from repeated episodes of infection with C. trachomatis. However, trichiasis recurrence rates post-surgery are very high. Methods for reducing post-surgical trichiasis recurrence need to be explored. This paper outlines the design of the Surgery for Trichiasis, Antibiotics to prevent Recurrence (STAR) Clinical Trial currently underway in Ethiopia. The STAR trial, funded by The National Eye Institute, is a randomized, controlled clinical trial of antibiotic use at time of trichiasis surgery, comparing topical tetracycline to single-dose azithromycin for the surgical patient and single-dose azithromycin for the surgical patient and all household members. The primary outcome is trichiasis recurrence at one-year. Data from this trial will be critical in helping to determine future policy on antibiotic treatment for C. trachomatis following surgery.</p>

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BT - Ophthalmic epidemiology
C1 - <p>http://www.ncbi.nlm.nih.gov/pubmed/16033749?dopt=Abstract</p>

DO - 10.1080/09286580591005769
IS - 4
J2 - Ophthalmic Epidemiol
LA - eng
N2 - <p>Trachoma is the leading infectious cause of blindness worldwide. Surgery is available to correct trichiasis, which results from repeated episodes of infection with C. trachomatis. However, trichiasis recurrence rates post-surgery are very high. Methods for reducing post-surgical trichiasis recurrence need to be explored. This paper outlines the design of the Surgery for Trichiasis, Antibiotics to prevent Recurrence (STAR) Clinical Trial currently underway in Ethiopia. The STAR trial, funded by The National Eye Institute, is a randomized, controlled clinical trial of antibiotic use at time of trichiasis surgery, comparing topical tetracycline to single-dose azithromycin for the surgical patient and single-dose azithromycin for the surgical patient and all household members. The primary outcome is trichiasis recurrence at one-year. Data from this trial will be critical in helping to determine future policy on antibiotic treatment for C. trachomatis following surgery.</p>

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PY - 2005
SP - 279
EP - 86
T2 - Ophthalmic epidemiology
TI - Surgery for trichiasis, antibiotics to prevent recurrence (STAR) clinical trial methodology.
VL - 12
SN - 0928-6586
ER -