TY - JOUR
KW - Snake venoms
KW - Protemics
KW - Genomics
KW - transcriptomics
KW - Bioinformatics
KW - mRNA
KW - synthetic biology
KW - venomics
KW -  toxin evolution
KW - Antivenom
KW - Therapeutic potential
AU - Roman-Ramos H
AU - Ho PL
AB - <jats:p>This comprehensive review explores the cutting-edge advancements in snake venom research, focusing on the integration of proteomics, genomics, transcriptomics, and bioinformatics. Highlighting the transformative impact of these technologies, the review delves into the genetic and ecological factors driving venom evolution, the complex molecular composition of venoms, and the regulatory mechanisms underlying toxin production. The application of synthetic biology and multi-omics approaches, collectively known as venomics, has revolutionized the field, providing deeper insights into venom function and its therapeutic potential. Despite significant progress, challenges such as the functional characterization of toxins and the development of cost-effective antivenoms remain. This review also discusses the future directions of venom research, emphasizing the need for interdisciplinary collaborations and new technologies (mRNAs, cryo-electron microscopy for structural determinations of toxin complexes, synthetic biology, and other technologies) to fully harness the biomedical potential of venoms and toxins from snakes and other animals.</jats:p>
BT - Toxins
DO - 10.3390/toxins16110458
IS - 11
LA - ENG
M3 - Article
N2 - <jats:p>This comprehensive review explores the cutting-edge advancements in snake venom research, focusing on the integration of proteomics, genomics, transcriptomics, and bioinformatics. Highlighting the transformative impact of these technologies, the review delves into the genetic and ecological factors driving venom evolution, the complex molecular composition of venoms, and the regulatory mechanisms underlying toxin production. The application of synthetic biology and multi-omics approaches, collectively known as venomics, has revolutionized the field, providing deeper insights into venom function and its therapeutic potential. Despite significant progress, challenges such as the functional characterization of toxins and the development of cost-effective antivenoms remain. This review also discusses the future directions of venom research, emphasizing the need for interdisciplinary collaborations and new technologies (mRNAs, cryo-electron microscopy for structural determinations of toxin complexes, synthetic biology, and other technologies) to fully harness the biomedical potential of venoms and toxins from snakes and other animals.</jats:p>
PB - MDPI AG
PY - 2024
SP - 1
EP - 36
T2 - Toxins
TI - Current Technologies in Snake Venom Analysis and Applications
UR - https://www.mdpi.com/2072-6651/16/11/458/pdf?version=1729850466
VL - 16
SN - 2072-6651
ER -