02777nas a2200337   4500000000100000008004100001260001200042653002300054653002200077653002900099653002100128100001600149700001400165700001500179700001800194700001400212700001500226700001400241700001800255700001900273700001800292700001500310700001300325700001500338700001200353245011700365856007300482300000900555520186100564022001402425       2024                            d  c03/202410aControl Strategies10aDevelopment goals10aLeishmaniasis challenges10aNeeds Assessment1 aBamorovat M1 aSharifi I1 aKhosravi A1 aAflatoonian M1 aAfshari S1 aSalarkia E1 aSharifi F1 aAflatoonian B1 aGharachorloo F1 aKhamesipour A1 aMohebali M1 aZamani O1 aShirzadi M1 aGouya M00aGlobal Dilemma and Needs Assessment Toward Achieving Sustainable Development Goals in Controlling Leishmaniasis.  uhttps://link.springer.com/content/pdf/10.1007/s44197-024-00190-z.pdf  a1-133 a<p>Leishmaniasis is a disease of poverty that imposes a devastating medical, social, and economic burden on over 1 billion people nationwide. To date, no in-depth study to analyze the major global challenges and needs assessment has been carried out. This investigation aimed to explore a comprehensive narrative review of leishmaniasis's main challenges and initially highlight obstacles that might impede the implementation of control measures. Also, we propose a specific list of priorities for needs assessment. The presence of socioeconomic factors, multiple clinical and epidemiological forms, various Leishmania species, the complexity of the life cycle, the absence of effective drugs and vaccines, and the lack of efficient vector and reservoir control make this organism unique and sophisticated in playing a tangled role to react tricky with its surrounding environments, despite extensive efforts and implementation of all-inclusive former control measures. These facts indicate that the previous strategic plans, financial support, and basic infrastructures connected to leishmaniasis surveillance are still insufficient. Strengthening the leishmaniasis framework in a context of accelerated programmatic action and intensification of cross-cutting activities along with other neglected tropical diseases (NTDs) is confidently expected to result in greater effectiveness, cost-benefit, and fruitful management. Sensitive diagnostics, effective therapeutics, and efficacious vaccines are vital to accelerating advancement toward elimination, and reducing morbidity/mortality and program costs. Collective actions devoted by all sectors and policy-makers can hopefully overcome technical and operational barriers to guarantee that effective and coordinated implementation plans are sustained to meet the road map for NTDs 2021- 2030 goals.</p>
  a2210-6014