03084nas a2200385   4500000000100000008004100001260001200042100001600054700001300070700001300083700001300096700001600109700001400125700001300139700001300152700001400165700001300179700001300192700001200205700001300217700001200230700001400242700001200256700001300268700001400281700001200295700001200307700001300319245018600332856009900518300000900617490000700626520205100633022001402684       2023                            d  c10/20231 aMcPherson S1 aGeleta D1 aTafese G1 aTafese T1 aBehaksira S1 aSolomon H1 aOljira B1 aMiecha H1 aGemechu L1 aDebebe K1 aKebede B1 aGebre T1 aKebede F1 aSeife F1 aTadesse F1 aMammo B1 aAseffa A1 aSolomon A1 aMabey D1 aMarks M1 aGadisa E00aPerceptions and acceptability of co-administered albendazole, ivermectin and azithromycin mass drug administration, among the health workforce and recipient communities in Ethiopia.  uhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011332&type=printable  a1-110 v173 a<p>Several neglected tropical diseases (NTDs) employ mass drug administration (MDA) as part of their control or elimination strategies. This has historically required multiple distinct campaigns, each targeting one or more NTDs, representing a strain on both the recipient communities and the local health workforce implementing the distribution. We explored perceptions and attitudes surrounding combined MDA among these two groups of stakeholders. Our qualitative study was nested within a cluster randomized non-inferiority safety trial of combined ivermectin, albendazole and azithromycin MDA. Using semi-structured question guides, we conducted 16 key informant interviews with selected individuals involved in implementing MDA within the participating district. To better understand the perceptions of recipient communities, we also conducted four focus group discussions with key community groups. Individuals were selected from both the trial arm (integrated MDA) and the control arm (standard MDA) to provide a means of comparison and discussion. All interviews and focus group discussions were led by fluent Afaan oromo speakers. Interviewers transcribed and later translated all discussions into English. The study team synthesized and analyzed the results via a coding framework and software. Most respondents appreciated the time and effort saved via the co-administered MDA strategy but there were some misgivings amongst community beneficiaries surrounding pill burden. Both the implementing health work force members and beneficiaries reported refusals stemming from lack of understanding around the need for the new drug regimen as well as some mistrust of government officials among the youth. The house-to-house distribution method, adopted as a COVID-19 prevention strategy, was by far preferred by all beneficiaries over central-point MDA, and may have led to greater acceptability of co-administration. Our data demonstrate that a co-administration strategy for NTDs is acceptable to both communities and health staff.</p>
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