02271nas a2200241   4500000000100000008004100001260005600042653002200098653001400120653001900134653001900153653002100172653002000193100001400213700001300227700001600240245011800256856006100374300001400435490000700449520154800456022002502004       2023                            d  bPenerbit Universiti Kebangsaan Malaysia (UKM Press)10amultidisciplinary10aAloe Vera10aChronic wounds10aClinical trial10awound prevention10awound treatment1 aIdrus ANA1 aRehman K1 aZulfakar MH00aA Systematic Review of the Clinical Effectiveness of Aloe Vera for the Prevention and Treatment of Chronic Wounds  uhttps://www.ukm.my/jsm/pdf_files/SM-PDF-52-6-2023/14.pdf  a1785-17940 v523 a<p>Aloe vera is an herbaceous and perennial plant that belongs to Liliaceae family and used for many medicinal purposes. Aloe vera have been associated with the treatment of skin burns and postoperative wound healing but not many clinical studies have been conducted to evaluate its effectiveness against chronic wounds such as pressure injury. The present study aimed to systematically review clinical trials investigating the effect of Aloe vera on the prevention and healing of chronic wounds. To identify all related published studies, Science Direct, Google Scholar, PubMed, and Ovid MEDLINE databases were searched in English language from the year 2015-2022. All clinical trials using Aloe vera gel, cream, or derivatives that included a control group with placebo or comparison with other treatments were included in the study according to the PRISMA selection process. In total, 11 trials that met the inclusion criteria were reviewed. The results of the studies showed successful use of Aloe vera in the prevention and treatment of chronic wounds including pressure injuries, chronic wound ulcers, diabetic foot ulcers, chronic anal fissures, and traumatic oral ulceration due to orthodontic appliances. Based on its safety and efficacy profile, this review concluded that Aloe verahas potential benefits to be used as a complementary or alternative treatment in chronic wounds along with conventional methods. Its ability to retain skin moisture and preservation of skin integrity supports its use in the prevention of ulcers.</p>
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