02347nas a2200421   4500000000100000008004100001260001200042653002400054653005700078653004000135100001700175700001200192700001700204700001300221700001300234700001400247700001800261700001300279700001200292700001400304700001300318700001400331700001500345700001400360700001400374700001300388700001700401700001700418700001500435700001500450700001700465245007400482856006700556300000800623490000600631520127400637022001401911       2022                            d  bMDPI AG10aInfectious Diseases10aPublic Health, Environmental and Occupational Health10aGeneral Immunology and Microbiology1 aPellegrino C1 aPatti G1 aCamporeale M1 aBelati A1 aNovara R1 aPapagni R1 aFrallonardo L1 aDiella L1 aGuido G1 aDe Vita E1 aTotaro V1 aSegala FV1 aVeronese N1 aCotugno S1 aBavaro DF1 aPutoto G1 aBevilacqua N1 aCastellani C1 aNicastri E1 aSaracino A1 aDi Gennaro F00aGuinea Worm Disease: A Neglected Diseases on the Verge of Eradication  uhttps://www.mdpi.com/2414-6366/7/11/366/pdf?version=1668060544  a3660 v73 a<p>Background: Dracunculiasis, also known as Guinea worm disease (GWD), is a neglected tropical disease (NTD) caused by a parasite (Dracunculus medinensis). In the past, dracunculiasis was known as “the disease of the empty granary” because of the difficulties patients had in going to work in fields or to school when affected by this disease. In tropical areas, the condition has been widespread in economically disadvantaged communities, and has been associated with reduced economic status and low levels of education. Methods: we searched PubMed, Scopus, Google Scholar, EMBASE, Cochrane Library, and WHO websites for literature addressing dracunculiasis published in the last 50 years. Results: by development and optimization of multi-layered control measures, transmission by the vector has been interrupted, but there are foci in several African countries with a high risk of compromising the results obtained in the control of this neglected disease. Conclusion: this review features state-of-the-art data on the infection prevalence, geographical distribution, diagnostics, parasite–host interactions, and the pathology of dracunculiasis. Also described are the current state and future perspectives for vector control and elimination strategies.</p>
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