02849nas a2200385   4500000000100000008004100001260005400042653001300096653002400109653001700133100001500150700001300165700001400178700001300192700001400205700001200219700001200231700001000243700001400253700001200267700001400279700001400293700001100307700001200318700001300330700001100343700001400354700001200368700001300380700001500393245016200408856007600570520179200646022002502438       2022                            d  bAmerican Society of Tropical Medicine and Hygiene10aVirology10aInfectious Diseases10aParasitology1 aGriswold E1 aEigege A1 aAdelamo S1 aMancha B1 aKenrick N1 aSambo Y1 aAjiji J1 aZam G1 aSolomon J1 aUrude R1 aKadimbo J1 aDanboyi J1 aMiri E1 aNute AW1 aRakers L1 aNebe O1 aAnyaike C1 aWeiss P1 aNoland G1 aRichards F00aImpact of Three to Five Rounds of Mass Drug Administration on Schistosomiasis and Soil-Transmitted Helminths in School-Aged Children in North-Central Nigeria  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294711/pdf/tpmd211207.pdf3 a<p>Nasarawa and Plateau states of north-central Nigeria have implemented programs to control schistosomiasis (SCH) and soil-transmitted helminths (STH) in children since the 1990s. Statewide mapping surveys were conducted in 2013, when 11,332 school-aged children were sampled from 226 schools. The local government areas (LGAs) then received varying combinations of mass drug administration (MDA) for the next 5 years. We revisited 196 (87%) schools in 2018 plus an additional six (202 schools in total), sampling 9,660 children. We calculated overall prevalence and intensity of infection and evaluated associations with gender; age; behaviors; water, sanitation, and hygiene (WASH); and treatment regimen. Urine heme detection dipsticks were used for Schistosoma hematobium in both surveys, with egg counts added in 2018. Stool samples were examined by Kato-Katz for Ascaris lumbricoides, Trichuris trichiura, Schistosoma mansoni, and hookworm. Schistosomiasis prevalence among sampled students dropped from 12.9% (95% confidence interval [CI]: 11.1–14.9%) to 9.0% (95% CI: 7.5–10.9%), a statistically significant change (P &lt; 0.05). In 2018, eight LGAs still had &gt; 1% of children with heavy-intensity schistosome infections. Prevalence of STH infection did not significantly change, with 10.8% (95% CI: 9.36–12.5%) of children positive in 2013 and 9.4% (95% CI: 8.0–10.9%) in 2018 (P = 0.182). Heavy-intensity STH infections were found in &lt; 1% of children with hookworm, and none in children with A. lumbricoides or T. trichiura in either study. The WASH data were collected in 2018, indicating 43.6% of schools had a latrine and 14.4% had handwashing facilities. Although progress is evident, SCH remains a public health problem in Nasarawa and Plateau states.</p>
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