02280nas a2200253   4500000000100000008004100001260001200042653003900054653005700093653001000150100001600160700001500176700001400191700001600205700001500221700001400236700002100250245011000271856004800381300000800429490000700437520156800444022001402012       2021                            d  bMDPI AG10aHealth, Toxicology and Mutagenesis10aPublic Health, Environmental and Occupational Health10aGPELF1 aMedeiros ZM1 aVieira AVB1 aXavier AT1 aBezerra GSN1 aLopes MDFC1 aBonfim CV1 aAguiar-Santos AM00aLymphatic Filariasis: A Systematic Review on Morbidity and Its Repercussions in Countries in the Americas  uhttps://www.mdpi.com/1660-4601/19/1/316/pdf  a3160 v193 a<p>The Global Program to Eliminate Lymphatic Filariasis (GPELF) is a program that aims to eliminate lymphatic filariasis by 2030. The GPELF strategy is based on interrupting transmission using mass drug administration (MDA) and, in parallel, managing morbidity cases. However, it has been seen that there is a shortage of research in the literature and public policies regarding this last pillar. In this study, we reviewed the literature and available information regarding the burden of filarial morbidity. In addition, we identified that in the Americas, the implementation of structured services with regard to morbidity assistance in the Americas was scarce. We formed a review that aimed to assess the pathogenesis, epidemiology, repercussions, and treatment of filarial morbidity in countries in the Americas where lymphatic filariasis is endemic. Structured searches were carried out on PubMed, LILACS, Scopus, and Web of Science databases without time and language restrictions. Three reviewers evaluated the 2150 studies and performed data extraction, and quality assessment by assigning scores to the studies found. The current literature and available information on the burden of filarial morbidity, as well as the implementation of structured services with regard to morbidity assistance in the Americas, were all found to be scarce. Now that this knowledge gap has been identified, both health services and researchers need to seek the implementation and enhancement of the maintenance of GPELF strategies that relate to the morbidity pillar.</p>
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