02853nas a2200265 4500000000100000008004100001260003400042653002400076653005700100653002100157653001700178100001300195700001600208700002000224700001600244700001300260700001300273700001400286245018500300856008000485300001400565490000800579520197500587022002502562 2021 d bOxford University Press (OUP) 10 aInfectious Diseases 10 aPublic Health, Environmental and Occupational Health 10 aGeneral Medicine 10 aParasitology 1 aNegash M 1 aChanyalew M 1 aT Gebresilase T 1 aSintayehu B 1 aAnteye T 1 aAseffa A 1 aNewport M 00 aRapid ethical appraisal of stakeholder views on research prior to undertaking immunopathogenesis studies on podoconiosis in northeast Ethiopia during a period of social instability uhttps://academic.oup.com/trstmh/article-pdf/115/9/1026/40303443/trab003.pdf a1026-1038 0 v115 3 aAbstract
Background
Undertaking research and attaining informed consent can be challenging when there is political unrest and community mistrust. Rapid ethical appraisal (REA) is a tool that uses qualitative methods to explore sociocultural issues that may affect the ethical conduct of research.
Methods
We used REA in northeast Ethiopia shortly following a period of unrest, during which violence against researchers occurred, to assess stakeholder perceptions of research, researchers and the informed consent process. We held 32 in-depth interviews and 2 focus group discussions.
Results
Most community members had little awareness about podoconiosis or healthcare research. Convincing the community to donate blood for research is challenging due to association with HIV testing. The attack on researchers was mainly motivated by the community's mistrust of their intentions against the background of a volatile political situation. Social media contributed to the spread of misinformation. Lack of community engagement was also a key contributing factor.
Conclusions
Using REA, we identified potential barriers to the informed consent process, participant recruitment for data and specimen collection and the smooth conduct of research. Researchers should assess existing conditions in the study area and engage with the community to increase awareness prior to commencing their research activities.
a0035-9203, 1878-3503