02846nas a2200313   4500000000100000008004100001260001200042653002000054653003500074653001000109100001300119700001500132700001900147700001200166700001600178700001500194700001600209700001300225700001100238700001500249700001300264700001600277700001200293700001300305245022600318856016200544520181200706022001402518       2020                            d  c05/202010aschistosomiasis10amass drug administration (MDA)10aSCORE1 aColley D1 aFleming FM1 aMatendechero S1 aKnopp S1 aRollinson D1 aUtzinger J1 aCastleman J1 aKittur N1 aKing C1 aCampbell C1 aKabole F1 aKinung'hi S1 aRamzy R1 aBinder S00aContributions of the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) to Schistosomiasis Control and Elimination: Key Findings and Messages for Future Goals, Thresholds, and Operational Research.  uhttp://www.ajtmh.org/docserver/fulltext/10.4269/ajtmh.19-0787/tpmd190787.pdf?expires=1589978689&id=id&accname=guest&checksum=234D78E7745308C33CB9FDDF47AFF18A3 a<p>Herein, we summarize what we consider are major contributions resulting from the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) program, including its key findings and key messages from those findings. Briefly, SCORE's key findings are as follows: 1) biennial mass drug administration (MDA) with praziquantel can control schistosomiasis to moderate levels of prevalence; 2) MDA alone will not achieve elimination; 3) to attain and sustain control throughout endemic areas, persistent hotspots need to be identified following a minimal number of years of annual MDA and controlled through adaptive strategies; 4) annual MDA is more effective than biennial MDA in high-prevalence areas; 5) the current WHO thresholds for decision-making based on the prevalence of heavy infections should be redefined; and 6) point-of-care circulating cathodic antigen urine assays are useful for  mapping in low-to-moderate prevalence areas. The data and specimens collected and curated through SCORE efforts will continue to be critical resource for future research. Besides providing critical information for program managers and revision of guidelines for schistosomiasis control and elimination, SCORE research and outcomes have identified additional questions that need to be answered as the schistosomiasis community continues to implement effective, evidence-based programs. An overarching contribution of SCORE has been increased cohesiveness within the schistosomiasis field-oriented community, thereby fostering new and productive collaborations. Based on SCORE's findings and experiences, we propose new approaches, thresholds, targets, and goals for control and elimination of schistosomiasis, and recommend research and evaluation activities to achieve these targets and goals.</p>  a1476-1645