02125nas a2200205   4500000000100000008004100001260001200042653002900054653003500083653001900118653002000137653004300157100001200200245010900212856008600321300000900407490000600416520148300422022001401905       2019                            d  c01/201910aNTD Modelling Consortium10amass drug administration (MDA)10aWHO Guidelines10aschistosomiasis10aElimination as a public health problem1 aGroup N00aInsights from quantitative and mathematical modelling on the proposed WHO 2030 goal for schistosomiasis.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820450/pdf/gatesopenres-3-14179.pdf  a15170 v33 a<p>Schistosomiasis remains one of the neglected tropical diseases (NTDs) impacting millions of people around the world. The World Health Organization (WHO) recently proposed a goal of elimination as a public health problem (EPHP) for schistosomiasis to be reached by 2030. Current WHO treatment guidelines for achieving EPHP focus on targeting school-aged children. The NTD Modelling Consortium has developed mathematical models to study schistosomiasis transmission dynamics and the impact of control measures. Our modelling insights on  have shown that EPHP is likely to be attainable in low to moderate prevalence settings using the current guidelines. However, as prevalence rises within higher settings, EPHP is less likely to be achieved unless both school-aged children and adults are treated (with coverage levels increasing with the adult burden of infection). We highlight the challenges that are faced by treatment programmes, such as non-adherence to treatment and resurgence, which can hinder progress towards achieving and maintaining EPHP. Additionally, even though EPHP may be reached, prevalence can still be high due to persisting infections. Therefore, without elimination of transmission, treatment will likely have to continue to maintain EPHP. Further modelling work is being carried out, including extending our results to . By providing these modelling insights, we aim to inform discussions on the goals and treatment guidelines for schistosomiasis.</p>  a2572-4754