03442nas a2200301   4500000000100000008004100001653001300042653003400055653001500089100001200104700001200116700001200128700001400140700001100154700001200165700001400177700001600191700001500207700001400222700001200236700001300248245009400261856009900355300001300454490000700467520265200474022001403126       2019                            d10aTrachoma10aPost-operative rehabilitation10aTrichiasis1 aGower E1 aMunoz B1 aRajak S1 aHabtamu E1 aWest S1 aMerbs S1 aHarding J1 aAlemayehu W1 aCallahan K1 aEmerson P1 aGebre T1 aBurton M00aPre-operative trichiatic eyelash pattern predicts post-operative trachomatous trichiasis.  uhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007637&type=printable  ae00076370 v133 a<p><strong>IMPORTANCE: </strong>Trichiasis surgery programs globally have faced high rates of poor surgical outcomes. Identifying correctable risk factors for improving long-term outcomes is essential for countries targeting elimination of trachoma as a public health problem.</p>

<p><strong>OBJECTIVE: </strong>To determine whether the location of trichiatic eyelashes prior to surgery influences development of post-operative trichiasis (PTT) within two years after surgery.</p>

<p><strong>DESIGN: </strong>Secondary data analysis of four randomized clinical trials evaluating methods to improve trichiasis surgery outcomes. These include the Surgery for Trichiasis, Antibiotics for Recurrence (STAR) trial, Partnership for Rapid Elimination of Trachoma (PRET-Surgery), absorbable versus silk sutures trial, and epilation versus surgery for minor trichiasis trial.</p>

<p><strong>SETTING: </strong>Primary trials were conducted in rural areas of Ethiopia and Tanzania.</p>

<p><strong>INTERVENTIONS OR EXPOSURES: </strong>Trichiasis surgery performed with either the bilamellar tarsal rotation procedure or posterior lamellar rotation procedure.</p>

<p><strong>MAIN OUTCOMES: </strong>Prevalence of PTT within two years after surgery, location of trichiatic eyelashes pre-operatively and post-operatively.</p>

<p><strong>RESULTS: </strong>6,747 eyelids that underwent first-time trichiasis surgery were included. PTT rates varied by study, ranging from 10-40%. PTT was less severe (based on number of trichiatic eyelashes) than initial trichiasis for 72% of those developing PTT, and only 2% of eyelids were worse at follow up than pre-operatively. Eyelids with central only-trichiasis pre-operatively had lower rates of PTT than eyelids with peripheral only trichiasis in each of the three trials that included severe TT cases. 10% of eyelids with peripheral trichiasis pre-operatively that develop PTT have central TT post-operatively.</p>

<p><strong>CONCLUSIONS AND RELEVANCE: </strong>Pre-operative central trichiasis is less likely than peripheral trichiasis to be associated with subsequent PTT. Regardless of type of surgery, surgeon skill levels, or pre-operative trichiasis severity, the presence of peripheral trichiasis pre-operatively is associated with higher rates of PTT. Making an incision that extends the length of the eyelid and adequately rotating the nasal and temporal aspects of the eyelid when suturing may help to minimize the chance of developing peripheral PTT.</p>

<p><strong>TRIAL REGISTRATION: </strong>ClinicalTrials.gov PRET: NCT00886015; Suture: NCT005228560; Epilation: NCT00522912.</p>
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