02451nas a2200469   4500000000100000008004100001653001200042653001500054653001400069653001000083653001700093100000900110700001300119700001400132700001100146700001300157700001000170700000900180700001300189700001200202700001000214700000900224700001100233700001500244700001000259700001300269700001000282700001200292700001300304700001300317700001600330700001500346700001500361700001200376700001100388245010300399856005800502300001000560490000600570520139100576022001401967       2018                            d10aleprosy10aMonitoring10aDetection10aChina10aEpidemiology1 aLe W1 aHaiqin J1 aDanfeng H1 aYing S1 aWenyue Z1 aJun Y1 aLi X1 aTiejun S1 aLimei S1 aJie L1 aDe W1 aYong N1 aYangying L1 aHao W1 aYanfei K1 aBin L1 aMaeda Y1 aDuthie M1 aMeiwen Y1 aHongsheng W1 aLiangbin Y1 aGuocheng Z1 aBaoxi W1 aHeng G00aMonitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010-2014.  uhttp://www.nature.com/articles/s41598-018-29753-4.pdf  a114070 v83 a<p>More than 100 counties, mainly in southwest China, report incidence rates of leprosy &gt;1/100,000. The current study analysed the epidemiology of leprosy in southwest China to improve our understanding of the transmission pattern and improve control programs. 207 counties were selected in southwest China. Leprosy patients and their household contacts were recruited. The data from the medical interview and the serological antileprosy antibody of the leprosy patients were analysed. A total of 2,353 new cases of leprosy were interviewed. The distribution of leprosy patients was partly associated with local natural and economic conditions, especially several pocket areas. A total of 53 from 6643 household contacts developed leprosy, and the incidence rate of leprosy in the household contacts was 364/100,000 person-years. We found that NDO-BSA attained higher positive rates than MMP-II and LID-1 regardless of clinical types, disability and infection time in leprosy patients. By means of combination of antigens, 88.4% patients of multibacillary leprosy were detected, in contrast to 59.9% in paucibacillary leprosy. Household contacts should be given close attention for the early diagnosis, disruption of disease transmission and precise control. Applications of serology for multi-antigens were recommended for effective coverage and monitoring in leprosy control.</p>
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