03238nas a2200229   4500000000100000008004100001653003900042653002500081653001000106653002500116100001100141700000900152700000900161700001000170700000900180700000900189245017600198300001200374490000700386520260100393022001402994       2013                            d10aNeglected tropical diseases (NTDs)10aSnakebite envenoming10aChina10aTraditional medicine1 aFang Z1 aHu G1 aHe B1 aYin Y1 aWu L1 aHe G00a[Study on clinical efficacy of combination of traditional Chinese medicine and western medicine in treatment of pit viper bites and peripheral blood inflammatory factors].  a1087-900 v383 a<p><strong>OBJECTIVE: </strong>To observe the clinical efficacy of combination of traditional Chinese medicine and western medicine in the treatment of patient bitten by agkistrodon halys pallas, and the changes in peripheral blood inflammatory factors (hs-PCR, IL-6, TNF-alpha).</p>

<p><strong>METHOD: </strong>Ninty-eight patients were divided into three groups according to their hospitalization dates: the western medicine group, in which 32 patients were treated with antivenom serum (6 000 U) for five days, once every day; the traditional Chinese medicine group, in which 32 patients were treated with anti pit viper No. 2 concentrated decoction (300 mL), twice to three times every day, for five days; and the combined traditional Chinese medicine and western medicine group, in which 35 patients were treated with the combination of Chinese and Western medicine treatment described above. Then blood samples of all of patients were obtained, and serum factors (hs-PCR, IL-6, TNF-alpha) in peripheral blood were measured by Elisa assay. Another 30 health volunteers were chosen as the normal control group.</p>

<p><strong>RESULT: </strong>The serum inflammatory factors were significantly higher in all patients of the three groups than that in healthy control before treatment (P &lt; 0.01), and decreased significantly after treatment. In particular, the more remarkable reduction was found in the combined traditional Chinese medicine and western medicine group compared with the western medicine group and the traditional medicine group (P &lt; 0.01). Symptom elimination in the three groups was superior to the western medicine group and the traditional medicine group at the first day and the third day of treatment (P &lt; 0.05, P &lt; 0.01). Total clinical effective rate was 100% in the combined traditional Chinese medicine and western medicine group, 84. 37% in the traditional medicine group and 65.62% in the western medicine group, the clinical effective rate of the combined traditional Chinese medicine and western medicine group was notably superior to that of the western medicine group and the traditional medicine group (P &lt; 0.01).</p>

<p><strong>CONCLUSION: </strong>The serum inflammatory factors increased significantly in patients bitten by agkistrodon halys pallas. Treatment with the combined traditional Chinese medicine and western medicine can significantly decrease the serum inflammatory factors, and increase clinical effect, with more obvious clinical efficacy compared with the western medicine group and the traditional medicine group.</p>
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