02636nas a2200361   4500000000100000008004100001653003900042653001100081653001000092653001700102653002200119653001700141100001100158700000900169700001100178700001000189700001100199700001100210700000900221700001000230700000900240700001700249700001100266700000900277700000900286700001200295245008200307856007700389300000700466490000600473520178100479022001402260       2016                            d10aNeglected tropical diseases (NTDs)10aDengue10aChina10aDengue virus10aDisease Outbreaks10aEpidemiology1 aXiao J1 aHe J1 aDeng A1 aLin H1 aSong T1 aPeng Z1 aWu X1 aLiu T1 aLi Z1 aRutherford S1 aZeng W1 aLi X1 aMa W1 aZhang Y00aCharacterizing a large outbreak of dengue fever in Guangdong Province, China.  uhttps://idpjournal.biomedcentral.com/track/pdf/10.1186/s40249-016-0131-z  a440 v53 a<p><strong>BACKGROUND: </strong>Dengue cases have been reported each year for the past 25 years in Guangdong Province, China with a recorded historical peak in 2014. This study aims to describe the epidemiological characteristics of this large outbreak in order to better understand its epidemic factors and to inform control strategies.</p>

<p><strong>METHODS: </strong>Data for clinically diagnosed and laboratory-confirmed dengue fever cases in 2014 were extracted from the China Notifiable Infectious Disease Reporting System. We analyzed the incidence and characteristics of imported and indigenous cases in terms of population, temporal and spatial distributions.</p>

<p><strong>RESULTS: </strong>A total of 45 224 dengue fever cases and 6 deaths were notified in Guangdong Province in 2014, with an incidence of 47.3 per 100 000 people. The elderly (65+ years) represented 11.7 % of total indigenous cases with the highest incidence (72.3 per 100 000). Household workers and the unemployed accounted for 23.1 % of indigenous cases. The majority of indigenous cases occurred in the 37(th) to 44(th) week of 2014 (September and October) and almost all (20 of 21) prefecture-level cities in Guangdong were affected. Compared to the non-Pearl River Delta Region, the Pearl River Delta Region accounted for the majority of dengue cases and reported cases earlier in 2014. Dengue virus serotypes 1 (DENV-1), 2 (DENV-2) and 3 (DENV-3) were detected and DENV-1 was predominant (88.4 %).</p>

<p><strong>CONCLUSIONS: </strong>Dengue fever is a serious public health problem and is emerging as a continuous threat in Guangdong Province. There is an urgent need to enhance dengue surveillance and control, especially for the high-risk populations in high-risk areas.</p>
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