03303nas a2200241   4500000000100000008004100001653003900042653003600081653003000117100001400147700001600161700001300177700001600190700001100206700001300217700001800230245015100248856009800399300001300497490000700510520253000517022001403047       2018                            d10aNeglected tropical diseases (NTDs)10aSoil-transmitted helminth (STH)10aGeographical distribution1 aSilver ZA1 aKaliappan S1 aSamuel P1 aVenugopal S1 aKang G1 aSarkar R1 aAjjampur SS R00aGeographical distribution of soil transmitted helminths and the effects of community type in South Asia and South East Asia - A systematic review.  uhttp://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0006153&type=printable  ae00061530 v123 a<p><strong>BACKGROUND: </strong>Soil-transmitted helminth (STH) infections are among the most prevalent neglected tropical diseases (NTD) worldwide. Since the publication of the WHO road map to combat NTD in 2012, there has been a renewed commitment to control STH. In this study, we analysed the geographical distribution and effect of community type on prevalence of hookworm, Trichuris and Ascaris in south Asia and south east Asia.</p>

<p><strong>METHODOLOGY: </strong>We conducted a systematic review of open-access literature published in PubMed Central and the Global Atlas of Helminth Infection. A total of 4182 articles were available and after applying selection criteria, 174 studies from the region were retained for analysis.</p>

<p><strong>PRINCIPAL FINDINGS: </strong>Ascaris was the commonest STH identified with an overall prevalence of 18% (95% CI, 14-23%) followed by Trichuris (14%, 9-19%) and hookworm (12%, 9-15%). Hookworm prevalence was highest in Laos, Vietnam and Cambodia. We found a geographical overlap in countries with high prevalence rates for Trichuris and Ascaris (Malaysia, Philippines, Myanmar, Vietnam and Bangladesh). When the effect of community type was examined, prevalence rates of hookworm was comparable in rural (19%, 14-24%) and tribal communities (14%, 10-19%). Tribal communities, however, showed higher prevalence of Trichuris (38%, 18-63%) and Ascaris (32%, 23-43%) than rural communities (13%, 9-20% and 14%, 9-20% respectively). Considerable between and within country heterogeneity in the distribution of STH (I2 &gt;90%) was also noted. When available data from school aged children (SAC) were analysed, prevalence of Ascaris (25% 16-31%) and Trichuris (22%, 14-34%) were higher than among the general population while that of hookworm (10%, 7-16%) was comparable.</p>

<p><strong>CONCLUSIONS/SIGNIFICANCE: </strong>Our analysis showed significant variation in prevalence rates between and within countries in the region. Highlighting the importance of community type in prevalence and species mix, we showed that tribal and rural communities had higher hookworm infections than urban communities and for ascariasis and trichuriasis, tribal populations had higher levels of infection than rural populations. We also found a higher prevalence of ascariasis and trichuriasis in SAC compared to the general population but comparable levels of hookworm infections. These key findings need to be taken into account in planning future MDA and other interventions.</p>
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