02677nas a2200277   4500000000100000008004100001653002500042653001700067653003900084653002500123653003000148653001000178653001300188100001000201700001400211700001000225700001600235700001900251700001300270245018500283856009800468300001300566490000700579520179900586022001402385       2017                            d10aWuchereria bancrofti10aTransmission10aNeglected tropical diseases (NTDs)10aMorbidity management10aLymphatic filariasis (LF)10aIndia10aChildren1 aKar S1 aDwibedi B1 aDas B1 aAgrawala BK1 aRamachandran C1 aHorton J00aLymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment.  uhttp://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005631&type=printable  ae00056310 v113 a<p><strong>BACKGROUND: </strong>Once interruption of transmission of lymphatic filariasis is achieved, morbidity prevention and management becomes more important. A study in Brugia malayi filariasis from India has shown sub-clinical lymphatic pathology with potential reversibility. We studied a Wuchereria bancrofti infected population, the major contributor to LF globally.</p>

<p><strong>METHODS: </strong>Children aged 5-18 years from Odisha, India were screened for W. bancrofti infection and disease. 102 infected children, 50 with filarial disease and 52 without symptoms were investigated by lymphoscintigraphy and then randomized to receive a supervised single oral dose of DEC and albendazole which was repeated either annually or semi-annually. The lymphatic pathology was evaluated six monthly for two years.</p>

<p><strong>FINDINGS: </strong>Baseline lymphoscintigraphy showed abnormality in lower limb lymphatics in 80% of symptomatic (40/50) and 63·5% (33/52) of asymptomatic children. Progressive improvement in baseline pathology was seen in 70·8, 87·3, 98·6, and 98·6% of cases at 6, 12, 18, and 24 months follow up, while in 4·2, 22·5, 47·9 and 64·8%, pathology reverted to normal. This was independent of age (p = 0·27), symptomatic status (p = 0·57) and semi-annual/bi-annual dosing (p = 0·46). Six of eleven cases showed clinical reduction in lymphedema of legs.</p>

<p><strong>INTERPRETATION: </strong>A significant proportion of a young W. bancrofti infected population exhibited lymphatic pathology which was reversible with annual dosage of DEC and albendazole. This provides evidence for morbidity prevention &amp; treatment of early lymphedema. It can also be used as a tool to improve community compliance during mass drug administration.</p>
  a1935-2735