02535nas a2200421   4500000000100000008004100001653001300042653001700055653001300072653002500085653001700110653002400127653001500151653000900166653002500175653001100200653001100211653001100222653001800233653002100251653002100272653001000293653001700303653002600320653002100346100001100367700001200378700001400390700001200404700001300416700001300429245011700442856007300559300001100632490000700643520144900650022001402099       2011                            d10aTrachoma10aTetracycline10aTanzania10aSecondary Prevention10aRisk Factors10aProspective Studies10aPrevalence10aMale10aLongitudinal studies10aInfant10aHumans10aFemale10aFamily Health10aEndemic Diseases10aChild, Preschool10aChild10aAzithromycin10aAnti-Bacterial Agents10aAge Distribution1 aWest S1 aStare D1 aMkocha HA1 aMunoz B1 aGaydos C1 aQuinn TC00aDo infants increase the risk of re-emergent infection in households after mass drug administration for trachoma?  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176068/pdf/z7g6040.pdf  a6040-20 v523 a<p><strong>PURPOSE: </strong>Mass treatment with azithromycin for trachoma endemic communities typically excludes infants under age 6 months, whose parents are provided with tubes of tetracycline to administer daily over 4 to 6 weeks. The authors sought to determine whether infants aged &lt;6 months are a source of re-emergent infection in their families after mass treatment in trachoma-endemic communities.</p>

<p><strong>METHODS: </strong>In a longitudinal study of all children aged less than 10 years in four communities, the authors identified 91 infants aged &lt;6 months living in 86 of 1241 households. All children aged</p>

<p><strong>RESULTS: </strong>The prevalence of infection at baseline in the infants was 5.9%. At 6 months post mass drug administration, the rate of infection among children older than 6 months and less than 10 years who resided in households with infants was 6.0% compared with 11.1% in children in households without infants (P = 0.18). After adjustment for age, sex, baseline infection status, and treatment, residing in a household with an infant was not associated with infection at 6 months (odds ratio [95% confidence interval] 0.50 [0.20-1.22]).</p>

<p><strong>CONCLUSIONS: </strong>This prospective study did not find evidence that living in a household with an infant increased the risk of infection 6 months post mass drug administration in other children residing in the household.</p>
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