02565nas a2200421   4500000000100000008004100001653001300042653001700055653001300072653001700085653001500102653001400117653000900131653002000140653001100160653001200171653001100183653002100194653002200215653001100237653000900248653002100257653001000278653002800288100001100316700001300327700001200340700001600352700001600368700001500384700001500399245006000414856016600474300001000640490000800650520147100658022001402129       1995                            d10aTrachoma10aTetracycline10aTanzania10aRisk Factors10aPrevalence10aOintments10aMale10aLogistic Models10aInfant10aHygiene10aHumans10aHealth Education10aFollow-Up Studies10aFemale10aFace10aChild, Preschool10aChild10aAdministration, Topical1 aWest S1 aMuñoz B1 aLynch M1 aKayongoya A1 aChilangwa Z1 aMmbaga B B1 aTaylor H R00aImpact of face-washing on trachoma in Kongwa, Tanzania.  uhttps://www.researchgate.net/profile/Matthew_Lynch2/publication/15374890_Impact_of_face-washing_on_trachoma_in_Kongwa_Tanzania/links/00b7d52d0758d05b97000000.pdf  a155-80 v3453 a<p>Observational studies have suggested that the prevalence of trachoma is lower in children with clean faces than in those with ocular or nasal discharge or flies on the face. We carried out a community-based randomised trial in three pairs of villages to assess the impact on trachoma of a face-washing intervention programme following a mass topical antibiotic treatment campaign. Six villages in Kongwa, Tanzania, were randomly assigned mass treatment plus the face-washing programme or treatment only. 1417 children aged 1-7 years in these villages were randomly selected and followed up for trachoma status and observations of facial cleanliness at baseline and 2, 6, and 12 months. At 12 months, children in the intervention villages were 60% more likely to have had clean faces at two or more follow-up visits than children in the control villages. The odds of having severe trachoma in the intervention villages were 0.62 (95% Cl 0.40-0.97) compared with control villages. A clean face at two or more follow-up visits was protective for any trachoma (odds ratio 0.58 [0.47-0.72]) and severe trachoma (0.35 [0.21-0.59]). This community-based participatory approach to face-washing intervention had variable penetration rates in the villages and was labour intensive. However, we found that, combined with topical treatment, community-based strategies for improving hygiene in children in trachoma-endemic villages can reduce the prevalence of trachoma.</p>
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