02869nas a2200289   4500000000100000008004100001653003900042653002500081653001000106653003400116100001100150700001000161700001800171700001500189700001200204700001600216700001400232700001300246700002500259700001300284245012200297856007800419300000900497490000600506520205300512022001402565       2010                            d10aNeglected tropical diseases (NTDs)10aLymphatic filariasis10aHaiti10aCommunity based interventions1 aBoyd A1 aWon K1 aMcClintock SK1 aDonovan CV1 aLaney S1 aWilliams SA1 aPilotte N1 aStreit T1 aBeau de Rochars MV E1 aLammie P00aA community-based study of factors associated with continuing transmission of lymphatic filariasis in Leogane, Haiti.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843627/pdf/pntd.0000640.pdf  ae6400 v43 a<p>Seven rounds of mass drug administration (MDA) have been administered in Leogane, Haiti, an area hyperendemic for lymphatic filariasis (LF). Sentinel site surveys showed that the prevalence of microfilaremia was reduced to &lt;1% from levels as high as 15.5%, suggesting that transmission had been reduced. A separate 30-cluster survey of 2- to 4-year-old children was conducted to determine if MDA interrupted transmission. Antigen and antifilarial antibody prevalence were 14.3% and 19.7%, respectively. Follow-up surveys were done in 6 villages, including those selected for the cluster survey, to assess risk factors related to continued LF transmission and to pinpoint hotspots of transmission. One hundred houses were mapped in each village using GPS-enabled PDAs, and then 30 houses and 10 alternates were chosen for testing. All individuals in selected houses were asked to participate in a short survey about participation in MDA, history of residence in Leogane and general knowledge of LF. Survey teams returned to the houses at night to collect blood for antigen testing, microfilaremia and Bm14 antibody testing and collected mosquitoes from these communities in parallel. Antigen prevalence was highly variable among the 6 villages, with the highest being 38.2% (Dampus) and the lowest being 2.9% (Corail Lemaire); overall antigen prevalence was 18.5%. Initial cluster surveys of 2- to 4-year-old children were not related to community antigen prevalence. Nearest neighbor analysis found evidence of clustering of infection suggesting that LF infection was focal in distribution. Antigen prevalence among individuals who were systematically noncompliant with the MDAs, i.e. they had never participated, was significantly higher than among compliant individuals (p&lt;0.05). A logistic regression model found that of the factors examined for association with infection, only noncompliance was significantly associated with infection. Thus, continuing transmission of LF seems to be linked to rates of systematic noncompliance.</p>
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