01539nas a2200265   4500000000100000008004100001653001300042653001700055653002100072653002500093653002200118653001200140653001600152653002300168653001600191653001500207100002100222700002600243245008500269856008700354300000700441490000700448520080400455022001401259       2016                            d10aSequelae10aSchwann cell10aPeripheral nerve10aMycobacterium leprae10aLeprosy reactions10aleprosy10aHistiocytes10aHansen’s disease10aElimination10aDisability1 aFranco-Paredes C1 aRodríguez-Morales AJ00aUnsolved matters in leprosy: a descriptive review and call for further research.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875741/pdf/12941_2016_Article_149.pdf  a330 v153 a<p>Leprosy, a chronic mycobacterial infection caused by Mycobacterium leprae, is an infectious disease that has ravaged human societies throughout millennia. This ancestral pathogen causes disfiguring cutaneous lesions, peripheral nerve injury, ostearticular deformity, limb loss and dysfunction, blindness and stigma. Despite ongoing efforts in interrupting leprosy transmission, large numbers of new cases are persistently identified in many endemic areas. Moreover, at the time of diagnosis, most newly identified cases have considerable neurologic disability. Many challenges remain in our understanding of the epidemiology of leprosy including: (a) the precise mode and route of transmission; (b) the socioeconomic, environmental, and behavioral factors that promote its transmission; and</p>
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