01818nas a2200349   4500000000100000008004100001653001300042653002900055653003500084653003300119653002200152653002100174653002100195653002300216653001200239653001100251653002100262653002000283653001200303653003100315653003900346100001400385700001600399700001400415700001400429245004900443856007700492300000900569490000600578520087000584022001401454       2008                            d10aZoonoses10aTrypanosomiasis, African10aTrypanosoma brucei rhodesiense10aTrypanosoma brucei gambiense10aTropical Medicine10aTropical Climate10aRural Population10aParasitic Diseases10aMalaria10aHumans10aDisabled Persons10aCost of Illness10aAnimals10aAfrica South of the Sahara10aAcquired Immunodeficiency Syndrome1 aFèvre EM1 aWissmann BV1 aWelburn S1 aLutumba P00aThe burden of human African trypanosomiasis.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602597/pdf/pntd.0000333.pdf  ae3330 v23 a<p>Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b. rhodesiense HAT is a zoonosis. We review current knowledge on the burden of HAT in sub-Saharan Africa, with an emphasis on the disability-adjusted life year (DALY), data sources, and methodological issues relating to the use of this metric for assessing the burden of this disease. We highlight areas where data are lacking to properly quantify the impact of these diseases, mainly relating to quantifying under-reporting and disability associated with infection, and challenge the HAT research community to tackle the neglect in data gathering to enable better evidence-based assessments of burden using DALYs or other appropriate measures.</p>
  a1935-2735