02770nas a2200421   4500000000100000008004100001260001600042653002800058653001300086653002300099653001700122653002200139100001200161700001400173700002100187700002000208700001400228700001600242700001500258700001100273700001500284700002300299700001300322700001300335700002600348700001400374700001400388700001300402700001300415700001400428700001100442700001300453245020200466856015300668300000700821520150600828022001402334       2025                            d  bElsevier BV10aChronic schistosomiasis10aMigrants10aSub-Saharan Africa10aPraziquantel10aEmpiric treatment1 aRoure S1 aVallès X1 aPérez-Quílez O1 aLópez-Muñoz I1 aValerio L1 aSoldevila L1 aChamorro A1 aAbad E1 aHegazy AHA1 aFernández-Rivas G1 aGorriz E1 aHerena D1 aFernández-Pedregal E1 aEspaña S1 aLlibre JM1 aIsnard M1 aBonet JM1 aEstrada O1 aPrat N1 aClotet B00aTherapeutic response to an empirical praziquantel treatment in long-staying sub-Saharan African migrants with positive Schistosoma serology and chronic symptoms: a prospective cohort study in Spain  uhttps://www.sciencedirect.com/science/article/pii/S1201971225000967/pdfft?md5=0de8b13694fe91cedb3b7380f039172d&pid=1-s2.0-S1201971225000967-main.pdf  a343 a<p><strong>Background:</strong>&nbsp;Sub-Saharan African migrants may be suffering from imported Schistosomiasis, which can evolve into chronic schistosomiasis. Positive response to empiric treatment with praziquantel may indicate the presence of persistent infection.</p>

<p><strong>Methods:</strong>&nbsp;We tested response to praziquantel in a cohort of sub-Saharan African migrants with probable chronic schistosomiasis. Tests were administered at baseline and 6 and 12 months.</p>

<p><strong>Results:</strong>&nbsp;Among 187 were eligible participants 149 completed follow-up. Of these 119 (79.9%) were males and 65 (43.6%) from Senegal. Median age was 43 years (IQR 35–51) and duration of residence in Europe was 17 years (IQR 12–21). The most prevalent clinical symptom was chronic abdominal pain (N=96, 64.4%), pelvic pain among males (N=55, 46.6%), and dysmenorrhea (N=21; 70.0%) among females. We observed a significant decrease (p&lt;0.001) in the number of signs and symptoms at 12 months, and 70.3% showed a total resolution of the symptoms, and significant decreases in transaminase levels, eosinophilia and abnormal glomerular filtration rates. The rates of clearance in positive ELISA and ICT tests were 54.7% and 24.3%.</p>

<p><strong>Conclusions:</strong>&nbsp;The positive response to praziquantel suggests that chronic schistosomiasis is a prevalent condition among long-staying African migrants. These results need to be confirmed in randomized clinical trials.</p>
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