02748nas a2200289   4500000000100000008004100001653001900042653001900061653002400080653001700104653001700121100002600138700001900164700001800183700002200201700002600223700002100249700002100270700002100291700001500312700001400327245008800341856015300429300000600582490000800588520186200596       2025                            d10aChagas disease10aVector control10aOne Health approach10aEpidemiology10aSurveillance1 aVelázquez-Ramírez D1 aDíaz-López H1 aGarza-Ramos J1 aLópez-Escalera J1 aEspinoza-Medinilla  E1 aIrecta-Nájera C1 aNavarro-López R1 aDelgado-Enciso I1 ade León A1 aDebboun M00aOne health research to mitigate health burden of American trypanosomiasis in Mexico  uhttps://www.sciencedirect.com/science/article/pii/S0001706X25000452/pdfft?md5=8537fb84f4d2c5fed6aecd908e3a1877&pid=1-s2.0-S0001706X25000452-main.pdf  a90 v2633 a<p>American trypanosomiasis (AT), or Chagas disease, is an ancient disease with an interesting history. Despite efforts to control AT, the global burden of this neglected vector-borne disease persists. More than six million people around the world are infected with&nbsp;<em>Trypanosoma cruzi</em>&nbsp;(<em>T. cruzi</em>), and about 75 million are at risk of infection in the Americas. Mexico is one of the countries most affected by AT with 4 million people at risk of infection with&nbsp;<em>T. cruzi.</em>&nbsp;Approximately 60 % of the accumulated confirmed cases occurred in the southeast region; however, an increase in the number of cases was observed in the northern states of the country in recent years. AT control efforts in Mexico focus on interrupting vector-borne disease transmission through integrated triatomine management and eliminating&nbsp;<em>T. cruzi</em>&nbsp;transmission through the congenital and blood transfusion routes. There is no specific prophylaxis beyond vector control. Research revealed the complexity of AT as a vector-borne disease system and its impact on the health of humans, domestic animals, and wildlife, which calls for comprehensive responses focused on transdisciplinary and multisectoral collaboration. One Health (OH) is an unifying approach aiming to achieve optimal health outcomes among people, animals, and their shared environment, which we suggest can be applied in collaborative research to enhance our understanding of AT as a vector-borne disease system with diverse components across epidemiological landscapes. Suggested action to implement OH research is presented herein for sustainable surveillance and control efforts to mitigate the health burden of AT that affects disproportionately poorer rural and semi-rural sectors of the population in Mexico and other Latin American countries.</p>