02869nas a2200337   4500000000100000008004100001260001600042653002700058653003200085653002500117653002300142653002000165653002600185100002600211700002200237700002400259700002900283700001900312700002000331700002100351700002400372700001300396700001600409700001800425245008000443856007000523300000700593490000700600520191000607022001402517       2025                            d  bElsevier BV10aSnakebite envenomation10aNeurovascular complications10aVenom-induced stroke10aHemorrhagic stroke10aIschemic stroke10aNeurological toxicity1 aVásconez-González J1 aDelgado-Moreira K1 aIzquierdo-Condoy JS1 ade Lourdes Noboa-Lasso M1 aGamez-Rivera E1 aLopez-Molina MB1 aLópez-Cortés A1 aTello-De-la-Torre A1 aCerda AT1 aMartinod DS1 aOrtiz-Prado E00aCerebrovascular events induced by venomous snake bites: A systematic review  uhttps://www.cell.com/action/showPdf?pii=S2405-8440%2825%2901160-0  a270 v113 a<p>Snake bites represent a critical public health issue, affecting approximately 2.7 million people globally each year. Around 20&nbsp;% of snake species are venomous, and their venom contains a complex array of toxins that can cause multi-organ damage, particularly affecting the nervous system, leading to both ischemic and hemorrhagic cerebrovascular events. This systematic review aims to compile and analyze data on cerebrovascular events associated with venomous snakebites. A comprehensive literature search was conducted using Scopus, PubMed, SciELO, and LILACS databases, with search terms including (“snake bite” OR “viper bite”) AND (“stroke” OR “hemorrhagic stroke” OR “ischemic stroke”). Studies in English, Spanish, French and Portuguese were reviewed, yielding 52 eligible articles reporting 73 cases of stroke following snakebites. Most cases were attributed to snakes from the&nbsp;<em>Viperidae</em>&nbsp;family, with 67.12&nbsp;% of cases occurring in males. Ischemic strokes were the most frequent, comprising 73.97&nbsp;% of reported cases. The most affected systems were the nervous, cardiovascular, and respiratory systems. Snakes from the&nbsp;<em>Bothrops</em>&nbsp;genera and&nbsp;<em>Daboia russelii</em>&nbsp;specie caused the widest range of symptoms, including altered consciousness, ptosis, hypertension, drowsiness, aphasia, and tachycardia. Stroke is a severe complication of snakebite envenomation. Regarding treatment, the articles included emphasize the use of antivenom serum; however, they do not go into detail about the specific management of cutaneous stroke due to a snakebite, whether ischemic or hemorrhagic It is crucial to develop standardized protocols for the management of snakebite-induced strokes and to conduct further research to identify the snake species whose venom poses the highest risk for cerebrovascular complications.</p>
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