03076nas a2200397   4500000000100000008004100001260003700042653002400079653001900103100001200122700002100134700001700155700001400172700001700186700001500203700001200218700001200230700001200242700001100254700001500265700001700280700001200297700001100309700001600320700001500336700001400351700001200365700001600377700001400393245011700407856009900524300001300623490000700636520202100643022001402664       2025                            d  bPublic Library of Science (PLoS)10aBias (Epidemiology)10aMass treatment1 aZongo D1 aTiendrebeogo JMA1 aOuedraogo WM1 aBagayan M1 aOuedraogo SH1 aBougouma C1 aNassa C1 aSerme M1 aNaré D1 aZida A1 aSangaré I1 aOuedraogo MO1 aHouck P1 aReid S1 aPhillips AE1 aMagalong J1 aWeaver AM1 aZhang Y1 aSoubeiga JK1 aTuanyok A00aEpidemiological situation of schistosomiasis in 16 districts of Burkina Faso after two decades of mass treatment  uhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012858&type=printable  ae00128580 v193 a<p>Background After two decades of mass drug administration (MDA) for schistosomiasis in Burkina Faso, an impact assessment was conducted in 16 health districts (HDs) between February 2023 to March 2024 to determine the epidemiological situation of schistosomiasis in school-aged children and facilitate the decision for sub-district level treatment decision.</p>

<p>Methodology/Principal findings A cross-sectional cluster survey was conducted with randomly selected children aged 5–14 years. Haemastix reagent strips were used to detect microhaematuria in urine, and urine filtration was used to detect and quantify Schistosoma haematobium eggs in children with microhaematuria. The Kato-Katz was used to detect and quantify S. mansoni eggs in fecal samples. The prevalence of infection and the prevalence of heavy-intensity (HI) infections were calculated. The overall prevalence of schistosomiasis was 2.4% (range: 0–11.1%) in 16 HDs, with the overall prevalence of HI infection of 0.9% (range: 0–4.2%). Four HDs (Tenkodogo, Batié, Sig-Nonghin, and Karangasso-Vigué) had a prevalence of HI infection from 1.3% to 4.2%. Forty-seven health areas still had an overall prevalence of 1.4–62.5%, with seven health areas in five HDs &gt;10%, and 29 health areas had a prevalence of HI infection from 1.4% to 22.9%. Boys had a higher prevalence of HI infections than girls. The prevalence of microhaematuria at 5.8% was significantly higher than that of S. haematobium infection by urine filtration at 2.3%, and Haemastix results were significantly associated with the intensity of infection.</p>

<p>Conclusions/Significance The results showed that progress has been made in eliminating schistosomiasis as a public health problem in the 16 HDs in Burkina Faso after two decades of mass treatment. However, hotspots of infections remain, with 29 health areas having a prevalence of HI infection above the 1% threshold. The results provide evidence for planning targeted sub-district-level treatment.</p>
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