02990nas a2200265   4500000000100000008004100001260001600042100001200058700002400070700001200094700001400106700001500120700001400135700001100149700001500160700001300175700001600188700001100204700001400215245013200229856015300361300001100514520218500525022001402710       2025                            d  bElsevier BV1 aMidzi N1 aMutsaka-Makuvaza MJ1 aPhiri I1 aPalatio K1 aBakajika D1 aZouré HM1 aJuma E1 aAnderson M1 aMwabvu R1 aBockarie MJ1 aCano J1 aNjenga SM00aShrinking the lymphatic filariasis map of Zimbabwe: Reassessing the population requiring treatment through confirmatory mapping  uhttps://www.sciencedirect.com/science/article/pii/S1201971225000153/pdfft?md5=24fedf62e9b13286f6826841ef61a2a7&pid=1-s2.0-S1201971225000153-main.pdf  a1077913 a<h3>Highlights for Review</h3>

<ul>
	<li>
	<p>Highlighted challenges and innovative interventions for eliminating LF</p>
	</li>
	<li>
	<p>Demonstrated the correct use of confirmatory mapping to determine endemic districts</p>
	</li>
	<li>
	<p>Discussed the results that informed the decision for using triple therapy in Zimbabwe</p>
	</li>
</ul>

<h3>Abstract</h3>

<h3 id="cesectitle0003">Objectives</h3>

<p>Zimbabwe is endemic for lymphatic filariasis (LF) with 39 districts identified for mass drug administration (MDA) in 2014. The objective of this study was to reassess the current population requiring MDA.</p>

<h3 id="cesectitle0004">Methods</h3>

<p>The LF confirmatory mapping method was used to evaluate the prevalence of circulating filarial antigens (CFA) among school-aged children (9–14 years) in previously endemic districts. This was achieved through a cross-sectional survey between 2021 and 2023, applying a cluster sampling approach across 39 districts, targeting 18,720 children to assess ongoing LF transmission.</p>

<h3 id="cesectitle0005">Results</h3>

<p>he findings revealed a significant decline in LF prevalence, with an overall rate of 0.43%. Importantly, 82.05% of districts previously identified as endemic were reclassified as non-endemic. Only seven districts retained endemic status, necessitating continued MDA using the triple-drug therapy regimen. Population estimates based on 2022 census data indicated that 1.19 million individuals across these districts require MDA, representing an 84.4% reduction compared to previous estimates. Despite the progress, the persistence of low-level transmission in certain districts highlights the need for sustained surveillance and morbidity management services, including hydrocele surgery and lymphedema care.</p>

<h3 id="cesectitle0006">Conclusion</h3>

<p>There was a significant reduction in the number of people requiring MDA. The decline in LF endemicity is attributed to a combination of factors, including prior rounds of MDA and vector control initiatives including historical interventions, such as DDT spraying against Human African Trypanosomiasis.</p>
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