02297nas a2200193 4500000000100000008004100001260001600042653002900058100001500087700001700102700001300119700002000132700001600152245012300168856015300291300001100444520163400455022001402089 2025 d bElsevier BV10aMass Drug Administration1 aBoateng CA1 aAfatodzie MS1 aMcLure A1 aKwansa-Bentum B1 ade Souza DK00aLymphatic filariasis transmission 10 years after stopping mass drug administration in the Gomoa West District of Ghana uhttps://www.sciencedirect.com/science/article/pii/S1201971225000141/pdfft?md5=1de0812f54dcc7ffc8253d6a5e6c6a54&pid=1-s2.0-S1201971225000141-main.pdf a1077903 a

OBJECTIVES

A survey was conducted 10 years after stopping MDA in the Gomoa West District of Ghana to assess the Wuchereria bancrofti prevalence in both human and mosquito populations.

METHODS

In seven communities, infection in humans was assessed using the filariasis test strip (FTS). Mosquitoes were collected once a month over six months using pyrethrum spray catches (PSC). The mosquitoes were analyzed for W. bancrofti infections, using dissection followed by poolscreening PCR.

RESULTS

FTS results showed that 2/524 (0.38%; 95% CI: 0.0% - 0.9%) individuals tested positive for antigen. Dissections revealed W. bancrofti infections in 5/107 Anopheles gambiae (4.7%: 95% CI: 2.2-8.5) from one community, with three mosquitoes harboring L3 larvae (2.8%: 95% CI: 0.9-7.5). PCR analysis of 683 mosquitoes in 57 pools revealed seven positive pools from two communities. The prevalence of infected mosquitoes by PCR for the district was 3.1% (95% CI: 0.5-24.0) for An. gambiae and 2.5% (95% CI: 0.4-23.5) for all Anopheles spp.

CONCLUSIONS

The infection rate in the Anopheles spp. exceeds the provisional 1% threshold suggested by WHO, indicating ongoing transmission risk ten years after stopping MDA. Further district-wide assessments are recommended to inform the scope of any interventions required in the Gomoa West district.

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