03017nas a2200349   4500000000100000008004100001260001200042653001400054653002500068653002000093653003200113653002000145653003300165653002200198100002000220700001700240700001700257700001500274700001500289700001100304700001400315700001600329700001700345700001300362700001300375700001100388245014100399856006200540300000900602520204200611022001402653       2024                            d  c11/202410aIndonesia10aLymphatic filariasis10aMeta‐analysis10aNeglected Tropical Diseases10aschistosomiasis10asoil‐transmitted helminths10aSystematic review1 aMurhandarwati E1 aProbandari A1 aKusumasari R1 aFerdiana A1 aKustanti C1 aDewi K1 aTarmizi S1 aWulandari L1 aSchierhout G1 aRomani L1 aKaldor J1 aNery S00aEffect of preventive chemotherapy for neglected tropical diseases in Indonesia from 1992 to 2022: A systematic review and meta-analysis.  uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111/tmi.14057  a1-113 a<p><strong>Objectives: </strong>This study aimed to describe the prevalence of lymphatic filariasis (LF), soil-transmitted helminthiasis (STH) and schistosomiasis (SC) in Indonesia before and after PC implementation through a systematic review and meta-analysis.</p>

<p><strong>Methods: </strong>Embase, MEDLINE, PubMed, Scopus, Web of Science and Google Scholar were searched for articles published between 1 January 1992 and 31 December 2022, reporting LF, STH and SC in Indonesia. Using the Ministry of Health lists of districts receiving PC programs, we identified whether data collection was conducted before or after PC implementation in that particular district. A meta-analysis was performed with a random-effects model applied to pool pre- and post-PC prevalence of LF, STH and SC.</p>

<p><strong>Results: </strong>Overall, 195 studies were included. The pooled prevalence of LF was 9.72% (95% CI, 5.56%-13.87%). The pre-PC pooled prevalence of LF was 11.48% (95% CI, 5.52%-17.45%). The prevalence decreased after PC implementation, and the pooled prevalence was 7.12% (95% CI, 1.79%-12.44%). The overall prevalence of STH was 35.16% (95% CI, 30.36%-39.96%). The pre-PC prevalence of STH was 36.29% (95% CI, 30.37%-42.20%). The post-PC prevalence of STH decreased at 31.93% (95% CI, 24.25%-39.62%), although the difference between before and after PC was not significant (p = 0.379). Only nine studies investigated the prevalence of SC; based on the random-effects model, the pooled prevalence was 21.90% (95% CI, 4.88%-38.92%). Owing to the scarcity of studies, we could not perform the funnel tests for publication bias and moderating variables of the pooled prevalence for SC.</p>

<p><strong>Conclusions: </strong>The prevalence of LF and STH decreased after PC implementation, although it was not significant. The difference for SC could not be assessed because of limited post-PC data. The uneven distribution of research and the lack of standardised sampling methods may not fully capture the situation.</p>
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