01889nas a2200253   4500000000100000008004100001260001600042653001400058653001900072653001500091653004100106100002200147700001900169700002100188700001600209700001300225700001700238700001300255245009900268856007500367300000900442520117000451022001401621       2024                            d  bElsevier BV10abiosensor10aCase detection10aBiomarkers10aSoil-transmitted helminth infections1 aCambra-Pellejà M1 aVan Lieshout L1 aBaptista-Pires L1 aVilaplana M1 aMuñoz J1 aGandasegui J1 aParolo C00aCrucial role of biosensors in the detection of helminth biomarkers in public health programmes  uhttps://www.thelancet.com/action/showPdf?pii=S2666-5247%2824%2900217-9  a1-143 a<p>Helminthiases are highly prevalent but neglected infections that affect more than 1·5&nbsp;billion people worldwide. Considering the worldwide prevalence of helminthiases, WHO has declared them a public health concern since 2001, necessitating rigorous control and elimination efforts. However, only a few reliable point-of-care diagnostic tests are available for assessing the effectiveness of public health interventions targeting helminthiases, thus increasing the risk of suboptimal outcomes, misallocation of resources, and emergence of drug-resistant helminths. This Review provides an introduction on helminthiases and strategies to achieve control, elimination, interruption in transmission, and eradication of these infections. The Review then comprehensively details the existent biosensors that can be used to detect these infections in human samples, focusing on their target biomarkers, the bioreceptors used, and the sensing readouts. The Review concludes with an in-depth discussion on the persistent challenges related to helminthiases, aiming to encourage the development of much-needed diagnostics specific to these neglected infections.</p>
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