01893nas a2200289   4500000000100000008004100001260001200042653001700054653001400071653001300085653002000098653001900118653000900137653002200146653001300168653002100181653001400202653002600216100001800242700001000260245006600270856006800336300000900404490000700413520116900420022001401589       2024                            d  bMDPI AG10aSnake venoms10aProtemics10aGenomics10atranscriptomics10aBioinformatics10amRNA10asynthetic biology10avenomics10a toxin evolution10aAntivenom10aTherapeutic potential1 aRoman-Ramos H1 aHo PL00aCurrent Technologies in Snake Venom Analysis and Applications  uhttps://www.mdpi.com/2072-6651/16/11/458/pdf?version=1729850466  a1-360 v163 a<jats:p>This comprehensive review explores the cutting-edge advancements in snake venom research, focusing on the integration of proteomics, genomics, transcriptomics, and bioinformatics. Highlighting the transformative impact of these technologies, the review delves into the genetic and ecological factors driving venom evolution, the complex molecular composition of venoms, and the regulatory mechanisms underlying toxin production. The application of synthetic biology and multi-omics approaches, collectively known as venomics, has revolutionized the field, providing deeper insights into venom function and its therapeutic potential. Despite significant progress, challenges such as the functional characterization of toxins and the development of cost-effective antivenoms remain. This review also discusses the future directions of venom research, emphasizing the need for interdisciplinary collaborations and new technologies (mRNAs, cryo-electron microscopy for structural determinations of toxin complexes, synthetic biology, and other technologies) to fully harness the biomedical potential of venoms and toxins from snakes and other animals.</jats:p>  a2072-6651