02562nas a2200241   4500000000100000008004100001260003700042653001900079653001000098653003000108653001200138653002600150653002100176653003100197653001600228100001900244245014100263856005700404300001400461490000700475520182400482022001402306       2024                            d  be-Century Publishing Corporation10aDrug Discovery10aGAPDH10aHSP70 Heat-Shock Proteins10aenolase10aMoonlighting proteins10aSchistosomiasis 10atriosephosphate isomerase,10avaccinomics1 aMotlhatlhedi K00aTherapeutic and vaccinomic potential of moonlighting proteins for the discovery and design of drugs and vaccines against schistosomiasis  uhttps://e-century.us/files/ajtr/16/9/ajtr0157125.pdf  a4279-43000 v163 a<p>Despite significant and coordinated efforts to combat schistosomiasis, such as providing clean water, sanitation, hygiene, and snail control, these strategies still fall short, as regions previously thought to be diseasefree have shown active schistosomiasis transmission. Therefore, it is necessary to implement integrated control methods, emphasizing vaccine development for sustainable control of schistosomiasis. Vaccination has significantly contributed to global healthcare and has been the most economically friendly method for avoiding pathogenic infections. Over the years, different vaccine candidates for schistosomiasis have been investigated with varying degrees of success in clinical trials with many not proceeding past the early clinical phase. Recently, proteins have been mentioned as targets for drug discovery and vaccine development, especially those with multiple functions in schistosomes. Moonlighting proteins are a class of proteins that can perform several functions besides their known functions. This multifunctional property is believed to have been expressed through evolution, where the polypeptide chain gained the ability to perform other tasks without undergoing any structural changes. Since proteins have gained more traction as drug targets, multifunctional proteins have thus become attractive for discovering and developing novel drugs since the drug can target more than one function. Moonlighting proteins are promising drug and vaccine candidates for diseases such as schistosomiasis, since they aid in disease promotion in the human host. This manuscript elucidates vital moonlighting proteins used by schistosomes to drive their life cycle and to ensure their survival in the human host, which can be used to develop anti-schistosomal therapeutics and vaccinomics.</p>
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