02221nas a2200289   4500000000100000008004100001260002400042653001800066653003500084653001600119653001000135100001300145700001600158700001500174700001400189700001500203700001800218700001400236700001600250700001300266245013200279856007800411300000900489490000700498520140100505022002501906       2024                            d  bFapUNIFESP (SciELO)10aWound Healing10aCalotrope (Calotropis procera)10aHanseniasis10aLatex1 aNunes MO1 aAlencar NMN1 aPontes MAA1 aSilva PGB1 aRabelo LMA1 aLima-Filho JV1 aSouza TFG1 aAlmeida MGG1 aRamos MV00aHealing of leprosy-associated chronic plantar wounds with a novel biomembrane containing latex proteins from Calotropis procera  uhttps://www.scielo.br/j/bjb/a/pptDFyPbb3wcsptpZ3CbRDG/?format=pdf&lang=en  a1-110 v843 a<p>Pre-clinical assays demonstrated that a 1% polyvinyl alcohol biomembrane containing latex proteins (10%) from the medicinal plant Calotropis procera was biocompatible and stimulated healing of incisional and excisional wounds in murine models, and the mechanistic aspects were established. The efficacy of the biomembrane (BioMemCpLP) to promote healing of chronic ulcers in leprosy patients was investigated. The study started with 28 volunteers. Five were excluded later due to different disconformities. Ulcers from 15 patients were continuously treated with BioMemCpLP for 56 days. Five patients were treated only with silver sulfadiazine and three patients received plain hydrocolloid wound dressings with high absorption capacity. In all cases, wound dressings were renewed three times a week for 56 days and ulcers were evaluated weekly for contraction and healing progress. The extent of the healed area in the ulcers treated with BioMemCpLP was greater than in the control groups. Approximately 88% of ulcers treated with BioMemCpLP were fully healed before day 56, against 6% in both control groups. This result was not correlated with age/gender, duration or location of ulcers, deformity or whether or not the patient was cured of leprosy. The results showed that BioMemCpLP was beneficial for treatment of ulcers suffered by leprosy patients without noticeable side effects.</p>
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