01474nas a2200193   4500000000100000008004100001653002600042653001200068653002900080653003100109653002200140100001400162700001300176700001200189245010100201856009800302300000800400520087200408       2024                            d10aPure neuritic leprosy10aDapsone10ahereditary spherocytosis10adapsone-induced haemolysis10aAnemia, Hemolytic1 aAgrawal S1 aBorkar M1 aDeoke S00aA rare case of pure neuritic leprosy with hereditary spherocytosis: implications for dapsone use  uhttps://leprosyreview.org/admin/public/api/lepra/website/getDownload/66bf15d3afaac13e560ca6a2  a1-53 a<p>We present a case of a 19-year-old female with the rare co-occurrence of pure neuritic leprosy (PNL) and hereditary spherocytosis (HS). Presenting with tingling, numbness, and sensory loss in her left hand but no skin lesions, she was diagnosed with PNL. Laboratory findings revealed HS, characterized by haemolysisprone spherical RBCs. The coexistence of these conditions posed unique challenges, especially with dapsone, which can induce haemolytic anaemia. The patient was treated with rifampicin, ofloxacin, clofazimine, and prednisolone, excluding dapsone to prevent haemolysis. This case highlights the need for comprehensive diagnostics and a multidisciplinary approach to manage complex cases involving leprosy and haemolytic disorders. Further studies are required to establish detailed management guidelines for such rare and concurrent conditions.</p>