01759nas a2200193   4500000000100000008004100001653001600042653001200058653002400070653003900094653001800133100001800151700001800169700002100187245011800208856007400326300000800400520115700408       2024                            d10aElimination10acontrol10aMathematical models10aNeglected tropical diseases (NTDs)10apolicy-making1 aVasconcelos A1 aNunes-Alves C1 aHollingsworth TD00aNew Tools and Nuanced Interventions to Accelerate Achievement of the 2030 Roadmap for Neglected Tropical Diseases  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11045012/pdf/ciae070.pdf  a1-63 a<p>The World Health Organization roadmap for neglected tropical diseases (NTDs) sets out ambitious targets for disease control and elimination by 2030, including 90% fewer people requiring interventions against NTDs and the elimination of at least 1 NTD in 100 countries. Mathematical models are an important tool for understanding NTD dynamics, optimizing interventions, assessing the efficacy of new tools, and estimating the economic costs associated with control programs. As NTD control shifts to increased country ownership and programs progress toward disease elimination, tailored models that better incorporate local context and can help to address questions that are important for decision-making at the national level are gaining importance. In this introduction to the supplement, New Tools and Nuanced Interventions to Accelerate Achievement of the 2030 Roadmap for Neglected Tropical Diseases, we discuss current challenges in generating more locally relevant models and summarize how the articles in this supplement present novel ways in which NTD modeling can help to accelerate achievement and sustainability of the 2030 targets.</p>