01504nas a2200253   4500000000100000008004100001260001200042653001800054653001900072653001600091653003400107653001900141653003200160653003200192653003100224100001600255700002500271700001300296245010400309300001400413490000700427520080200434022001401236       2024                            d  c07/202410aaminopyridine10aChagas disease10aDrug Design10ahuman african trypanosiomasis10aleischmaniasis10aNeglected Tropical Diseases10apharmacochemical properties10apharmacokinetic properties1 aMustière R1 aDassonville-Klimpt A1 aSonnet P00aAminopyridines in the development of drug candidates against protozoan neglected tropical diseases.  a1357-13730 v163 a<p>Neglected tropical diseases (NTDs) pose a major threat in tropical zones for impoverished populations. Difficulty of access, adverse effects or low efficacy limit the use of current therapeutic options. Therefore, development of new drugs against NTDs is a necessity. Compounds containing an aminopyridine (AP) moiety are of great interest for the design of new anti-NTD drugs due to their intrinsic properties compared with their closest chemical structures. Currently, over 40 compounds with an AP moiety are on the market, but none is used against NTDs despite active research on APs. The aim of this review is to present the medicinal chemistry work carried out with these scaffolds, against protozoan NTDs:&nbsp;Trypanosoma cruzi,&nbsp;Trypanosoma brucei&nbsp;or&nbsp;Leishmania spp.</p>
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