02780nas a2200349   4500000000100000008004100001260001200042653002100054653001200075653002800087653002200115653002500137653002100162653002400183100001500207700001500222700001600237700001300253700001500266700001500281700001600296700001500312700001300327700001500340700001700355245016600372856013000538300000900668490000600677520173300683022001402416       2024                            d  bMDPI AG10aCôte d’Ivoire10aMapping10apreventive chemotherapy10asampling approach10aSchool-aged children10a schistosomiasis10aSchistosoma mansoni1 aSékré JK1 aOuattara M1 aDiakité NR1 aBassa FK1 aAssaré RK1 aKouadio JN1 aCoulibaly G1 aLoukouri A1 aOrsot MN1 aUtzinger J1 aN’Goran EK00aEffectiveness of Three Sampling Approaches for Optimizing Mapping and Preventive Chemotherapy against Schistosoma mansoni in the Western Part of Côte d’Ivoire  uhttps://mdpi-res.com/d_attachment/tropicalmed/tropicalmed-09-00159/article_deploy/tropicalmed-09-00159.pdf?version=1720952278  a1-130 v93 a<p>The elimination of schistosomiasis as a public health problem by 2030 is one of the main goals put forth in the World Health Organization’s roadmap for neglected tropical diseases. This study aimed to compare different sampling approaches to guide mapping and preventive chemotherapy. A cross-sectional parasitological survey was conducted from August to September 2022 in the health districts of Biankouma, Ouaninou, and Touba in the western part of Côte d’Ivoire. The prevalence and intensity of Schistosoma mansoni infection were assessed in children aged 5–14 years using three sampling approaches. The first approach involved a random selection of 50% of the villages in the health districts. The second approach involved a random selection of half of the villages selected in approach 1, thus constituting 25% of the villages in the health district. The third approach consisted of randomly selecting 15 villages from villages selected by approach 2 in each health district. The overall prevalence of S. mansoni was 23.5% (95% confidence interval (CI): 19.9–27.6%), 21.6% (95% CI: 17.1–26.8%), and 18.3% (95% CI: 11.9–27.1%) with the first, second, and third approach, respectively. The respective geometric mean S. mansoni infection intensity was 117.9 eggs per gram of stool (EPG) (95% CI: 109.3–127.3 EPG), 104.6 EPG (95% CI: 93.8–116.6 EPG), and 94.6 EPG (95% CI 79.5–112.7 EPG). We conclude that, although randomly sampling up to 50% of villages in a health district provides more precise population-based prevalence and intensity measures of S. mansoni, randomly selecting only 15 villages in a district characterized by low heterogeneity provides reasonable estimates and is less costly.</p>
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