01789nas a2200181   4500000000100000008004100001260004400042653002400086653002100110100001400131700001400145700001100159700001300170700001600183245007000199520131300269022002501582       2024                            d  bSpringer Science and Business Media LLC10aInfectious diseases10aCardiomyopathies1 aSabino EC1 aNunes MCP1 aBlum J1 aMolina I1 aRibeiro ALP00aCardiac involvement in Chagas disease and African trypanosomiasis3 a<p>Trypanosomiases are diseases caused by various species of protozoan parasite in the genus&nbsp;<em>Trypanosoma</em>, each presenting with distinct clinical manifestations and prognoses. Infections can affect multiple organs, with&nbsp;<em>T</em><em>rypanosoma</em>&nbsp;<em>cruzi</em>&nbsp;predominantly affecting the heart and digestive system, leading to American trypanosomiasis or Chagas disease, and&nbsp;<em>T</em><em>rypanosoma</em>&nbsp;<em>brucei</em>&nbsp;primarily causing a disease of the central nervous system known as human African trypanosomiasis or sleeping sickness. In this Review, we discuss the effects of these infections on the heart, with particular emphasis on Chagas disease, which continues to be a leading cause of cardiomyopathy in Latin America. The epidemiology of Chagas disease has changed substantially since 1990 owing to the emigration of over 30 million Latin American citizens, primarily to Europe and the USA. This movement of people has led to the global dissemination of individuals infected with&nbsp;<em>T. cruzi</em>. Therefore, cardiologists worldwide must familiarize themselves with Chagas disease and the severe, chronic manifestation — Chagas cardiomyopathy — because of the expanded prevalence of this disease beyond traditional endemic regions.</p>
  a1759-5002, 1759-5010