@article{99265,
  keywords = {drug development, Drug Discovery, Human African Trypanosomiasis, Malaria, Neglected Tropical Diseases, Product development partnerships, Public-private partnerships, Repurposing know-how, schistosomiasis, Swiss Tropical and Public Health Institute},
  author = {Meier L and Antillon M and Burri C and Chitnis N and Endriss Y and Keiser J and Moore S and Müller P and Penny M and Voss T and Mäser P and Utzinger J},
  title = {Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute.},
  abstract = {<p>In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as a powerful approach to accelerate drug discovery and development processes, often at a fraction of the costs of de novo developments. For 80 years, collaborating within a network of partnerships, the Swiss Tropical and Public Health Institute (Swiss TPH) has been working along a value chain from innovation to validation and application to combat poverty-related diseases. This article presents an overview of selected know-how repurposing initiatives conducted at Swiss TPH with a particular emphasis on the exploration of drug development pathways in the context of neglected tropical diseases and other infectious diseases of poverty, such as schistosomiasis, malaria and human African trypanosomiasis.</p>
},
  year = {2023},
  journal = {Chimia},
  volume = {77},
  pages = {582-592},
  month = {09/2023},
  issn = {0009-4293},
  url = {https://www.chimia.ch/chimia/article/view/2023_582/6292},
  doi = {10.2533/chimia.2023.582},
  language = {eng},
}