@article{98057,
  keywords = {Infectious Diseases, Parasitology, Paediatric indications, Paediatric age-appropriate formulations, Neglected tropical diseases (NTDs), Oral Formulation, Preventive chemotherapy (PC)},
  author = {Al-Obaidi I and Krome AK and Wagner KG and Pfarr K and Kuesel AC and Batchelor HK},
  title = {Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young children},
  abstract = {<p>It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data (labelling) is a well-recognised problem for all diseases affecting children. For neglected tropical diseases, the fact that they affect to a large extent poor and marginalised populations in low- and middle-income countries means that there is a low economic return on investment into paediatric development activities compared to other diseases [e.g. human immunodeficiency virus (HIV)]. This review provides an introduction to issues affecting the availability and development of paediatric population-relevant data and appropriate formulations of drugs for NTDs. We are summarising why age-appropriate formulations are important to ensure treatment efficacy, safety and effectiveness, outline initiatives to increase the number of paediatric indications/labelling and age-appropriate formulations, provide an overview of publicly available information on the formulations of oral drugs for NTDs relative to age appropriateness and give an introduction to options for age-appropriate formulations. The review completes with ‘case studies’ of recently developed paediatric formulations for NTDs, complemented by case studies for fixed-dose combinations for HIV infection in children since such formulations have not been developed for NTDs.</p>
},
  year = {2022},
  journal = {Parasites &amp; Vectors},
  volume = {15},
  pages = {1-22},
  publisher = {Springer Science and Business Media LLC},
  issn = {1756-3305},
  url = {https://parasitesandvectors.biomedcentral.com/counter/pdf/10.1186/s13071-022-05546-7.pdf},
  doi = {10.1186/s13071-022-05546-7},
  language = {Eng},
}