@article{28648,
  keywords = {Trachoma, Tetracycline, Tanzania, Secondary Prevention, Risk Factors, Prospective Studies, Prevalence, Male, Longitudinal studies, Infant, Humans, Female, Family Health, Endemic Diseases, Child, Preschool, Child, Azithromycin, Anti-Bacterial Agents, Age Distribution},
  author = {West S and Stare D and Mkocha HA and Munoz B and Gaydos C and Quinn TC},
  title = {Do infants increase the risk of re-emergent infection in households after mass drug administration for trachoma?},
  abstract = {<p><strong>PURPOSE: </strong>Mass treatment with azithromycin for trachoma endemic communities typically excludes infants under age 6 months, whose parents are provided with tubes of tetracycline to administer daily over 4 to 6 weeks. The authors sought to determine whether infants aged &lt;6 months are a source of re-emergent infection in their families after mass treatment in trachoma-endemic communities.</p>

<p><strong>METHODS: </strong>In a longitudinal study of all children aged less than 10 years in four communities, the authors identified 91 infants aged &lt;6 months living in 86 of 1241 households. All children aged</p>

<p><strong>RESULTS: </strong>The prevalence of infection at baseline in the infants was 5.9%. At 6 months post mass drug administration, the rate of infection among children older than 6 months and less than 10 years who resided in households with infants was 6.0% compared with 11.1% in children in households without infants (P = 0.18). After adjustment for age, sex, baseline infection status, and treatment, residing in a household with an infant was not associated with infection at 6 months (odds ratio [95% confidence interval] 0.50 [0.20-1.22]).</p>

<p><strong>CONCLUSIONS: </strong>This prospective study did not find evidence that living in a household with an infant increased the risk of infection 6 months post mass drug administration in other children residing in the household.</p>
},
  year = {2011},
  journal = {Investigative ophthalmology & visual science},
  volume = {52},
  pages = {6040-2},
  issn = {1552-5783},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176068/pdf/z7g6040.pdf},
  doi = {10.1167/iovs.11-7372},
  language = {eng},
}