@article{102040,
  keywords = {Chronic schistosomiasis, Migrants, Sub-Saharan Africa, Praziquantel, Empiric treatment},
  author = {Roure S and Vallès X and Pérez-Quílez O and López-Muñoz I and Valerio L and Soldevila L and Chamorro A and Abad E and Hegazy AHA and Fernández-Rivas G and Gorriz E and Herena D and Fernández-Pedregal E and España S and Llibre JM and Isnard M and Bonet JM and Estrada O and Prat N and Clotet B},
  title = {Therapeutic response to an empirical praziquantel treatment in long-staying sub-Saharan African migrants with positive Schistosoma serology and chronic symptoms: a prospective cohort study in Spain},
  abstract = {<p><strong>Background:</strong>&nbsp;Sub-Saharan African migrants may be suffering from imported Schistosomiasis, which can evolve into chronic schistosomiasis. Positive response to empiric treatment with praziquantel may indicate the presence of persistent infection.</p>

<p><strong>Methods:</strong>&nbsp;We tested response to praziquantel in a cohort of sub-Saharan African migrants with probable chronic schistosomiasis. Tests were administered at baseline and 6 and 12 months.</p>

<p><strong>Results:</strong>&nbsp;Among 187 were eligible participants 149 completed follow-up. Of these 119 (79.9%) were males and 65 (43.6%) from Senegal. Median age was 43 years (IQR 35–51) and duration of residence in Europe was 17 years (IQR 12–21). The most prevalent clinical symptom was chronic abdominal pain (N=96, 64.4%), pelvic pain among males (N=55, 46.6%), and dysmenorrhea (N=21; 70.0%) among females. We observed a significant decrease (p&lt;0.001) in the number of signs and symptoms at 12 months, and 70.3% showed a total resolution of the symptoms, and significant decreases in transaminase levels, eosinophilia and abnormal glomerular filtration rates. The rates of clearance in positive ELISA and ICT tests were 54.7% and 24.3%.</p>

<p><strong>Conclusions:</strong>&nbsp;The positive response to praziquantel suggests that chronic schistosomiasis is a prevalent condition among long-staying African migrants. These results need to be confirmed in randomized clinical trials.</p>
},
  year = {2025},
  journal = {International Journal of Infectious Diseases},
  pages = {34},
  publisher = {Elsevier BV},
  issn = {1201-9712},
  url = {https://www.sciencedirect.com/science/article/pii/S1201971225000967/pdfft?md5=0de8b13694fe91cedb3b7380f039172d&pid=1-s2.0-S1201971225000967-main.pdf},
  doi = {10.1016/j.ijid.2025.107873},
  language = {ENG},
}