@conference{100698,
  keywords = {Prodrugs, Drug delivery, NTD drugs, Pharmacokinetics, Pharmacodynamics, pharmacological  optimization},
  author = {Mathew TS and Abubakar MY and Danbatta MN and Adam AB and Shamsudden R},
  title = {Prodrug Strategies for Improving the Efficacy of NTD Drugs: a Chemical and Pharmacology Review},
  abstract = {<p>Neglected tropical diseases (NTDs) are a significant global health issue, affecting millions in low-income areas. Traditional treatments are often ineffective, causing side effects. Prodrug strategies could improve the pharmacological profiles of NTD drugs, addressing issues like efficacy, toxicity, and pharmacokinetics. Prodrug strategies offer a promising approach to enhancing the efficacy of NTD drugs by optimizing their delivery, activation, and pharmacological activity. This review provides a comprehensive overview of prodrug design, development, and optimization for NTD drugs, highlighting chemical and pharmacological aspects. This review discusses prodrug strategies for antiparasitic, anti-inflammatory, and immunomodulatory agents, focusing on activation mechanisms, pharmacokinetic and pharmacodynamic studies, and structure-activity relationships. It also addresses challenges in prodrug development, stability, formulation, and regulatory considerations. The review aims to inspire innovative solutions for improving NTD drug efficacy and patient outcomes.</p>
},
  year = {2024},
  journal = {Bilsel International Kibyra Scientific Researches Congress},
  pages = {1-14},
  url = {https://www.researchgate.net/profile/Ansar-Adam/publication/382828017_PRODRUG_STRATEGIES_FOR_IMPROVING_THE_EFFICACY_OF_NTD_DRUGS_A_CHEMICAL_AND_PHARMACOLOGY_REVIEW/links/66ada7b38f7e1236bc32bf2c/PRODRUG-STRATEGIES-FOR-IMPROVING-THE-EFFICACY-OF-NTD-DRUGS-A},
  language = {ENG},
}